ABSTRACT
Actinic keratosis (AK) is a kind of precancerous skin lesions related to long-term light exposure, and photodynamic therapy is one of its main treatment methods. Compared with conventional photodynamic therapy, daylight photodynamic therapy (DL-PDT) with daylight as a light source has advantages of more convenient operation, less pain and higher patient acceptability, but it is liable to be affected by weather and other factors. DL-PDT is suitable for the treatment of grade Ⅰ or Ⅱ AK on the head and face, and its efficacy may be affected by pretreatment, photosensitizers, irradiation dose, etc. This review mainly elaborates the advantages of DL-PDT and introduces its operation methods to help clinicians choose the best treatment protocol for AK.
ABSTRACT
ABSTRACT Objective To evaluate if distress respiratory decreases after using helium-oxygen mixture in pediatric patients diagnosed with bronchospasm. Methods This is a retrospective, non-randomized study that included patients diagnosed with bronchospasm, who received a helium-oxygen mixture at three time points (30, 60, and 120 minutes) according to the organization protocol singular, and were admitted to the intensive care unit, from January 2012 to December 2013. This protocol includes patients with bronchospasm who sustained a modified Wood score of moderate to severe, even after one hour of conventional treatment. Results Twenty children were included in the study. The mean score of severity of the disease at the initial moment was 5.6 (SD:2.0), and at moment 120 minutes, it was 3.4 (SD: 2.0). The severity score showed a significant improvement as of 30 minutes (p<0.001). Conclusion The use of helium-oxygen mixture proved to be effective in diminishing the respiratory distress score for children with airway obstructions; it should be considered a supplementary therapeutic option, together with drug therapy, in specific clinical situations.
RESUMO Objetivo Avaliar se o desconforto diminui após o uso da mistura hélio-oxigênio em pacientes pediátricos com diagnóstico de broncoespasmo. Métodos Estudo retrospectivo, não randomizado, no qual foram incluídos pacientes com diagnóstico de broncoespasmo que utilizaram a mistura hélio-oxigênio em três momentos (30, 60 e 120 minutos), seguindo o protocolo institucional, internados em unidade de terapia intensiva pediátrica de janeiro de 2012 a dezembro 2013. Este protocolo incluía pacientes com diagnóstico de broncoespasmo que mantivessem escore de Wood modificado de moderado a grave, mesmo após 1 hora de tratamento convencional. Resultados Foram incluídas 20 crianças neste estudo. A média do escore de gravidade da doença no momento zero foi de 5,6 (DP:2,0) e, no momento 120 minutos, 3,4 (DP: 2,0). O escore de gravidade apresentou melhora significante a partir dos 30 minutos (p<0,001). Conclusão A utilização da mistura hélio-oxigênio mostrou-se eficaz na redução do escore de desconforto respiratório de crianças com doenças obstrutivas e deve ser considerada recurso terapêutico complementar à terapia medicamentosa em situações clínicas específicas.
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Oxygen Inhalation Therapy/methods , Bronchial Spasm/therapy , Helium/administration & dosage , Time Factors , Severity of Illness Index , Intensive Care Units, Pediatric , Retrospective Studies , Treatment Outcome , Non-Randomized Controlled Trials as TopicABSTRACT
Background: Acute resuscitation is one of the most challenging aspects of caring for burned patients. Although the Parkland formula is still the most common employed resuscitation formula worldwide, it is far from a perfect solution. Materials and Methods: This is a prospective observational study, which was carried out over a period of 3 years. A total of 50 patients were enrolled. Modified Parkland formula and heliotherapy were used in the management of moderate degree burns. Result: Out of 50 patients with Moderate degree of burns 47 survived (mortality rate: 6%). One of the deaths in occurred during the period of resuscitation (day 2). While the other two deaths were related to septic shock. Urine Output (ml/kg/h) of 0.72 ± 0.06 and 0.92 ± 0.05 was noted on day 1 and 2, respectively. Conclusion: Modified Parkland formula and heliotherapy proved to be effective in our set-up in comparison to the conventional Parkland formula and protocol for management of burns, as reflected in the published literature, thus, we recommend multicentric trials to test the efficacy of this technique, in management of burns.
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Spa therapy constitutes the use of mineral springs and thermal mud to soothe and heal various ailments. Like the mineral springs, seas and oceans are also important centers for spa therapy of which the most important is Dead Sea (DS). DS has been famous for thousands of years for its miraculous curative and cosmetic properties. Intensive research is going on using DS minerals in a wide range of dermatological conditions especially psoriasis, atopic dermatitis, vitiligo and other eczemas and several papers have been published in various international and pharmacological journals.